Repeated Evolution of Transcript Dosage Compensation of Independently Formed Nematode Neo-X Chromosomes.

ABSTRACT: Ohno proposed that, during the origin of X/Y sex chromosomes from a pair of autosomes, X-linked genes must double their per-allele expressions to compensate for the degeneration of their Y homologs. Whether Ohno's hypothesis holds in the nematode Caenorhabditis elegans remains unresolved despite that C. elegans is a model for studying between-sex X chromosome dosage compensation. Genome sequencing revealed independent fusions of an ancestrally autosomal linkage group to the X chromosome in C. elegans and Brugia malayi, two species belonging to different suborders of the order Rhabditida, allowing testing Ohno's hypothesis in repeated origins of neo-X chromosomes from the same autosomal linkage group. For each C. elegans X-linked gene and its autosomal ortholog in Pristionchus pacificus, we

SUBMITTER: Li J 

PROVIDER: S-EPMC11981892 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature