Examining the genetic relationship between Alzheimer's disease, schizophrenia and their shared risk factors using genomic structural equation modelling.

ABSTRACT: Epidemiological studies have demonstrated an association between dementia and schizophrenia. There is a significant symptom overlap between the two disorders-psychosis is seen in 50% of patients with Alzheimer's disease and cognitive impairment is a key feature of schizophrenia. Whether these overlapping clinical presentations reflect shared aetiology is unclear. Therefore, we aimed to model the genetic correlation between Alzheimer's disease, schizophrenia and their shared risk factors using genomic structural equation modelling to identify potentially overlapping biological pathways between these traits. We measured genetic correlation between Alzheimer's disease, schizophrenia and 13 shared risk factors, including body fat percentage, less education, alcohol intake, insomnia, loneliness

SUBMITTER: Almeida E Sousa I 

PROVIDER: S-EPMC11981896 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature