Perisomatic ultrastructure efficiently classifies cells in mouse cortex.

ABSTRACT: Mammalian neocortex contains a highly diverse set of cell types. These cell types have been mapped systematically using a variety of molecular, electrophysiological and morphological approaches^1-4. Each modality offers new perspectives on the variation of biological processes underlying cell-type specialization. Cellular-scale electron microscopy provides dense ultrastructural examination and an unbiased perspective on the subcellular organization of brain cells, including their synaptic connectivity and nanometre-scale morphology. In data that contain tens of thousands of neurons, most of which have incomplete reconstructions, identifying cell types becomes a clear challenge for analysis⁵. Here, to address this challenge, we present a systematic survey of the somatic

SUBMITTER: Elabbady L 

PROVIDER: S-EPMC11981918 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature