Inhibitory specificity from a connectomic census of mouse visual cortex.

ABSTRACT: Mammalian cortex features a vast diversity of neuronal cell types, each with characteristic anatomical, molecular and functional properties¹. Synaptic connectivity shapes how each cell type participates in the cortical circuit, but mapping connectivity rules at the resolution of distinct cell types remains difficult. Here we used millimetre-scale volumetric electron microscopy² to investigate the connectivity of all inhibitory neurons across a densely segmented neuronal population of 1,352 cells spanning all layers of mouse visual cortex, producing a wiring diagram of inhibition with more than 70,000 synapses. Inspired by classical neuroanatomy, we classified inhibitory neurons based on targeting of dendritic compartments and developed an excitatory neuron classificat

SUBMITTER: Schneider-Mizell CM 

PROVIDER: S-EPMC11981935 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature