Leveraging a phased pangenome for haplotype design of hybrid potato.

ABSTRACT: The tetraploid genome and clonal propagation of the cultivated potato (Solanum tuberosum L.)^1,2 dictate a slow, non-accumulative breeding mode of the most important tuber crop. Transitioning potato breeding to a seed-propagated hybrid system based on diploid inbred lines has the potential to greatly accelerate its improvement³. Crucially, the development of inbred lines is impeded by manifold deleterious variants; explaining their nature and finding ways to eliminate them is the current focus of hybrid potato research^4-10. However, most published diploid potato genomes are unphased, concealing crucial information on haplotype diversity and heterozygosity^11-13. Here we develop a phased potato pangenome graph of 60 haplotypes from cultivated diploi

SUBMITTER: Cheng L 

PROVIDER: S-EPMC11981936 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature