Functional connectomics reveals general wiring rule in mouse visual cortex.

ABSTRACT: Understanding the relationship between circuit connectivity and function is crucial for uncovering how the brain computes. In mouse primary visual cortex, excitatory neurons with similar response properties are more likely to be synaptically connected^1-8; however, broader connectivity rules remain unknown. Here we leverage the millimetre-scale MICrONS dataset to analyse synaptic connectivity and functional properties of neurons across cortical layers and areas. Our results reveal that neurons with similar response properties are preferentially connected within and across layers and areas-including feedback connections-supporting the universality of 'like-to-like' connectivity across the visual hierarchy. Using a validated digital twin model, we separated neuronal tuning into fea

SUBMITTER: Ding Z 

PROVIDER: S-EPMC11981947 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature