Candidate Biomarkers Associated With Circulating Tumor Cell Status in Metastatic Colorectal Cancer.

ABSTRACT:

Background

Colorectal cancer (CRC) ranks as the third most prevalent cancer worldwide. Recent studies suggest the promising potential of microRNAs (miRNA) in predicting the status of circulating tumor cells (CTC), and their combined analyses could pave the way for significant advancements in assessing the risk of metastatic cancer. Here, we investigate the circulating miRNA signatures associated with CTC status in metastatic CRC (mCRC).

Methods

The CTC status of mCRC patients was assessed using AdnaTest ColonCancer technology, which detects tumor cells using an immunomagnetic approach and characterizes them based on colon-specific surface markers. The miRNA profiles were analyzed using the Agilent miRNA microarray in 8 CTC-positive, 8 CTC-negative, and eight healthy individu

SUBMITTER: Dogan B 

PROVIDER: S-EPMC11981952 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature