Microrchidia OsMORC6 Positively Regulates Cadmium Tolerance and Uptake by Mediating DNA Methylation in Rice.

ABSTRACT: Rice (Oryza sativa) is an extremely important global food crop. However, cadmium (Cd) contamination in paddy fields poses a serious threat to human health worldwide. To generate low-Cd or Cd-free rice germplasms, it is essential to understand the molecular mechanisms involved in Cd tolerance, uptake, and translocation from soil to plant. In this study, we identify three Microrchidia proteins, OsMORC6a, OsMORC6b, and OsMORC6c, that regulate Cd tolerance and accumulation, although they do not alter the translocation of Cd from roots to shoots. Knockout of all three genes results in reducing Cd accumulation and increasing sensitivity to Cd stress. Furthermore, transcriptome analysis reveals 1,127 differentially expressed genes (DEGs) in the morc6abc mutants, which are significantly enriched i

SUBMITTER: Tan J 

PROVIDER: S-EPMC11981988 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature