Immunomodulating platelet-mimicking nanoparticles for AIE-based enhanced photodynamic immunotherapy against lung cancer.

ABSTRACT: Lung cancer has become the leading cause of cancer related death worldwidely. Nowadays, immune checkpoint inhibitor (ICI) plays an important part in the treatment of lung cancer. However, immunologically cold tumor microenvironment (TME) hinders the therapeutic effect of ICIs. Herein, immunomodulating platelet-mimicking nanoparticles (DM@PM NPs) were designed by encapsulating the aggregation-induced emission (AIE) photosensitizer DTZ-TPA-DCN with acidic-sensitive bond modified DSPE-PEG-MET (MET, metformin) and then coating with a platelet membrane (PM). Notably, DM@PM NPs can selectively accumulate in tumor profiting from the tumor-targeting and antiphagocytic capabilities of PM. In the acidic tumor tissues, the acidic-sensitive released MET of DSPE-PEG-MET plays as a kind of ICI and degra

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11982056 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature