Longitudinal description of health-related quality of life and depressive symptoms in polyQ spinocerebellar ataxia patients.

ABSTRACT:

Introduction

Due to limited treatment options, managing symptoms has dominated care for Spinocerebellar Ataxia (SCA). Little attention has been given to health-related quality of life (HRQoL) and depressive symptoms experienced by patients across disease duration.

Objective

To investigate the course of HRQoL and the severity of depressive symptoms in SCA from disease onset to 26 years after onset and identify influencing factors.

Methods

We analyzed data from two longitudinal SCA cohorts, the EUROSCA (European Spinocerebellar Ataxia Registry) and ESMI study (European Spinocerebellar Ataxia Type 3/Machado-Joseph Disease Initiative). Multilevel mixed-effects models were employed to demonstrate the course of HRQoL and depressive symptoms severity to investigate the role

SUBMITTER: Iskandar A 

PROVIDER: S-EPMC11982069 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature