Pre- and post-diagnosis body weight trajectories in patients with localized renal cell cancer.

ABSTRACT:

Purpose

Obesity in mid-life is a well-established risk factor for developing renal cell carcinoma (RCC); however, patients with RCC who are obese at the time of diagnosis have more favorable survival outcomes. To get better insight into the obesity paradox and determine the extent to which weight around diagnosis is stable, we examined pre- and post-diagnosis weight changes in patients with localized RCC.

Methods

We included 334 patients with localized RCC from the prospective cohort ReLife who self-reported body weight at multiple time points ranging from 2 years before to 2 years after diagnosis. Multivariable linear mixed-effects regression models were used to compare weight at each timepoint to weight at diagnosis for the overall study population, as well as stratified b

SUBMITTER: Vrieling A 

PROVIDER: S-EPMC11982074 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature