Clinical and MRI features contributing to the clinico-radiological dissociation in a large cohort of people with multiple sclerosis.

ABSTRACT:

Background

People with Multiple Sclerosis (PwMS) often show a mismatch between disability and T2-hyperintense white matter (WM) lesion volume (LV), that in general is referred to as the clinico-radiological paradox.

Objectives

This study aimed to understand how an extensive clinical, neuropsychological, and MRI analysis could better elucidate the clinico-radiological dissociation in a large cohort of PwMS.

Methods

Clinical scores, such as Expanded Disability Status Scale (EDSS), 9 Hole Peg Test (9HPT), 25-foot Walking Test (25-FWT), Paced Auditory Serial Addition Test at 3 s (PASAT3), Symbol digit Modalities Test (SDMT), demographics, and 3 T-MRI of 717 PwMS and 284 healthy subjects (HS) were downloaded from the INNI database. Considering medians of LV and EDSS scores

SUBMITTER: Ojha A 

PROVIDER: S-EPMC11982092 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature