Alternative pre-mRNA processing regulates cell-type specific expression of the IL4l1 and NUP62 genes.

ABSTRACT:

Background

Given the complexity of higher organisms, the number of genes encoded by their genomes is surprisingly small. Tissue specific regulation of expression and splicing are major factors enhancing the number of the encoded products. Commonly these mechanisms are intragenic and affect only one gene.

Results

Here we provide evidence that the IL4I1 gene is specifically transcribed from the apparent promoter of the upstream NUP62 gene, and that the first two exons of NUP62 are also contained in the novel IL4I1_2 variant. While expression of IL4I1 driven from its previously described promoter is found mostly in B cells, the expression driven by the NUP62 promoter is restricted to cells in testis (Sertoli cells) and in the brain (e.g., Purkinje cells). Since NUP62 is itself

SUBMITTER: Wiemann S 

PROVIDER: S-EPMC1198218 | biostudies-literature | 2005 Jul

REPOSITORIES: biostudies-literature