Understanding embolus transport and source to destination mapping of thromboemboli in hemodynamics driven by left ventricular assist device.

ABSTRACT: Left Ventricular Assist Devices (LVADs) are a key treatment option for patients with advanced heart failure, but they carry a significant risk of thromboembolic complications. While improved LVAD design, and systemic anticoagulation regimen, have helped mitigate thromboembolic risks, ischemic stroke due to adverse thromboembolic events remains a major concern with current LVAD therapies. Improved understanding of embolic events, and embolus movement to the brain, is critical to develop techniques to minimize risks of occlusive embolic events such as a stroke after LVAD implantation. Here, we address this need, and devise a quantitative in silico framework to characterize thromboembolus transport and distrbution in hemodynamics driven by an operating LVAD. We conduct systematic numerical ex

SUBMITTER: Majee S 

PROVIDER: S-EPMC11982188 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature