Spike-phase coupling of subthalamic neurons to posterior perisylvian cortex predicts speech sound accuracy.

ABSTRACT: Speech provides a rich context for understanding how cortical interactions with the basal ganglia contribute to unique human behaviors, but opportunities for direct human intracranial recordings across cortical-basal ganglia networks are rare. Here we have recorded electrocorticographic signals in the cortex synchronously with single units in the basal ganglia during awake neurosurgeries where participants spoke syllable repetitions. We have discovered that individual subthalamic nucleus (STN) neurons have transient (200 ms) spike-phase coupling (SPC) events with multiple cortical regions. The spike timing of STN neurons is locked to the phase of theta-alpha oscillations in the supramarginal and posterior superior temporal gyrus during speech planning and production. Speech sound errors oc

SUBMITTER: Vissani M 

PROVIDER: S-EPMC11982203 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature