Deletion of Fgf14 confers resilience to basal and stress-induced depressive-like behavior and reduces anxiety in mice.

ABSTRACT: Depression is a mental illness characterized by despair behavior, inability to feel pleasure, and social withdrawal. Causes are not yet clarified, but stress is a condition that induces depression. Neuronal alterations, comprising maladaptive neuronal plasticity and excitability, are present in both responses to stress and depression. Fibroblast growth factor 14 (Fgf14) controls neuronal excitability and proper action potential firing by stabilizing voltage-dependent sodium (Na_v) channels into the axon. Fgf14-Na_v channels complex is regulated by glycogen synthase kinase 3. Recently, Fgf14 has been genetically associated to depression. However, little is known about its role in controlling stress-induced depression. This study demonstrates that female Fgf14^-/-

SUBMITTER: Montarolo F 

PROVIDER: S-EPMC11982207 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature