The crucial role of neutrophil extracellular traps and IL-17 signaling in indomethacin-induced gastric injury in mice.

ABSTRACT: The homeostasis of gastric mucosa is extremely delicate. Neutrophils, the most abundant immune cells in human circulation, are regarded crutial in the regulation of gastric mucosal immune response. Non-steroidal anti-inflammatory drugs (NSAIDs) induced gastric injury is the second major reason for gastric ulcers. The relations between neutrophils and Indomethacin-induced gastric injury are not fully understood. A mouse model of gastric injury was established using Indomethacin, followed by proteomic analysis (raw data are available via ProteomeXchange with identifier PXD058482). GO functional annotations and KEGG pathway enrichment analysis were conducted on significant differential proteins. The formation of neutrophil extracellular traps (NETs) was observed using ELISA and immunofluoresc

SUBMITTER: Hou Y 

PROVIDER: S-EPMC11982219 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature