Association between clonal hematopoiesis and periodontitis: a two-sample mendelian randomization study.

ABSTRACT: Clonal hematopoiesis (CH) is an age-associated phenomenon characterized by the proliferation of blood cells carrying somatic mutations. Recent studies suggest a potential link between CH and periodontitis, but the causal relationship remains unclear. A two-sample Mendelian randomization (MR) analysis was implemented, examining whether CH phenotypes are causally associated with periodontitis. CH phenotypes included overall clonal hematopoiesis (CH-overall), CH with a DNMT3A mutation (CH-DNMT3A), CH with a TET2 mutation (CH-TET2), large clones (CH-large), and small clones (CH-small). Genetic instruments were derived from genome-wide association studies, and the inverse-variance weighted (IVW) method was the primary analytical approach. Sensitivity analyses and reverse MR were also performed

SUBMITTER: Qiu F 

PROVIDER: S-EPMC11982285 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature