Interaction between depressive state and high-fat diet and its impact on behavioral and body weight changes in male mice.

ABSTRACT: Depression and obesity are common chronic diseases in modern society. Meta-analyses consistently reveal a bidirectional relationship: individuals with depression have a higher risk of obesity, while obese individuals are more prone to depression. High-fat diet (HFD) consumption is a risk factor of obesity. However, the impact of depression on obesity and the underlying mechanisms remains unclear. We aim to assess the impact of a long-term depressive state throughout adulthood on body weight changes induced by HFD, and whether HFD affects depressive state in mice. We established a depression mouse model using a Chronic Unpredictable Mild Stress (CUMS) paradigm. Following the stress period, male mice were fed with a normal diet or a HFD for seven weeks prior to behavioral tests and body weig

SUBMITTER: Hu J 

PROVIDER: S-EPMC11982303 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature