Epigenetic regulation of HOXA2 expression affects tumor progression and predicts breast cancer patient survival.

ABSTRACT: Accumulating evidence suggests that genetic and epigenetic biomarkers hold potential for enhancing the early detection and monitoring of breast cancer (BC). Epigenetic alterations of the Homeobox A2 (HOXA2) gene have recently garnered significant attention in the clinical management of various malignancies. However, the precise role of HOXA2 in breast tumorigenesis has remained elusive. To address this point, we conducted high-throughput RNA sequencing and DNA methylation array studies on laser-microdissected human BC samples, paired with normal tissue samples. Additionally, we performed comprehensive in silico analyses using large public datasets: TCGA and METABRIC. The diagnostic performance of HOXA2 was calculated by means of receiver operator characteristic curves. Its prognostic signi

SUBMITTER: De Palma FDE 

PROVIDER: S-EPMC11982354 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature