Antiviral potential of Melissa officinalis extracts against influenza and emerging coronaviruses.

ABSTRACT: Melissa officinalis is a perennial medicinal plant traditionally used for its diverse biological activities, including antiviral properties. This study investigates the antiviral efficacy of various extracts, including water, acetone, alkaloid, non-alkaloid, ethanol, and methanol extracts, against influenza A (H1N1), SARS-CoV-2, and MERS-CoV. The water extract demonstrated significant inhibitory effects on SARS-CoV-2 (IC₅₀ = 421.9 µg/mL) and MERS-CoV (IC₅₀ = 222.1 µg/mL) in Vero E6 cells (an African green monkey kidney cell line), with a CC₅₀ of 4221 µg/mL, indicating a favorable selectivity index. Additionally, it exhibited strong activity against H1N1 in Madin-Darby canine kidney cell line (MDCK cells) (IC₅₀ = 57.30 µg/mL, CC₅₀ = 307

SUBMITTER: Alsahafi T 

PROVIDER: S-EPMC11982357 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature