Genetic susceptibility to recurrent vulvovaginal candidiasis in an African population from Nairobi, Kenya.

ABSTRACT: Vulvovaginal candidiasis (VVC) affects 75% of women worldwide at least once in their lifetime, with up to 9% of women experiencing recurrent episodes (RVVC). Genetic differences may play a role in women developing recurrent VVC infections. Thus, we investigated genetic host factors that may increase the risk of RVVC in women from an African population. We conducted a case-control study in women in Nairobi Kenya, to identify genetic risk factors for RVVC. Our genome-wide association study compared women with RVVC (n = 174) to those with acute VVC (n = 157), and with controls (n = 347). The control group included both symptomatic but uninfected women (n = 246) and asymptomatic/healthy women (n = 101). We identified several genomic variants linked to increased RVVC susceptibility (P < 10

SUBMITTER: Omosa-Manyonyi GS 

PROVIDER: S-EPMC11982394 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature