Direct observation of importin α family member KPNA1 in axonal transport with or without a schizophrenia-related mutation.

ABSTRACT: Karyopherin α1 (KPNA1)/(human importin α5; mouse importin α1) facilitates cargo transport into the nucleus by forming a complex with a nuclear localization sequence containing cargo and importin β1 (IPOB1). The elevated KPNA1 expression in neurons and the correlation between mutations and psychiatric disorders suggest its broader significance beyond nucleocytoplasmic transport. Although KPNA1 is localized in the neurites of neurons, its role in axonal transport mechanisms remains unclear, and data on the connection between psychiatric disorders and signaling at the periphery of neurons remain limited. To address this knowledge gap, we investigated the dynamics of KPNA1 and related factors within axons. Our results showed that many of the axonal KPNA1 did not form a complex with IPOB1 in no

SUBMITTER: Mizuno K 

PROVIDER: S-EPMC11982482 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature