The aggregation tendencies of the signal peptide regions of prone and not prone to aggregate proteins.

ABSTRACT: Signal peptides are a sequence of peptides located at the N-terminus of proteins and determine the protein secretion pathway and their destinations. The N-region is positively charged and influences the orientation of translocation. When linked to the protein, signal peptides provide protection against misfolding events and the formation of amyloid fibrils, which are related to neurodegenerative and inflammatory diseases. An earlier study from our research group demonstrated the tendency/predisposition of misfolding and seeding events of the synthetic signal peptide of serum amyloid A1 (SAA1), which originates from humans and other animal species. The current study explores the propensity for misfolding of fourteen different synthetic signal peptides of both prone-to-aggregate and non-pron

SUBMITTER: Horgan NG 

PROVIDER: S-EPMC11982493 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature