Elucidating the Role of Trem2 in Lipid Metabolism and Neuroinflammation.

ABSTRACT:

Background

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive impairment and neuroinflammation. Astrocytes play a key role in the neuroinflammatory environment of AD, especially through lipid metabolism regulation. However, the mechanisms by which astrocytes, particularly through the triggering receptor expressed on myeloid cells 2 (Trem2) receptor, contribute to lipid dysregulation and neuroinflammation in AD remain inadequately understood.

Methods

We employed an AD mouse model and integrated single-cell RNA sequencing (scRNA-seq), transcriptomics, and high-throughput metabolomics to analyze lipid metabolism and inflammatory profiles in astrocytes. Differential gene expression was further validated with the GEO database, and in vitro and in 

SUBMITTER: Zhao C 

PROVIDER: S-EPMC11982525 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature