Immunotherapy with conventional type-1 dendritic cells induces immune memory and limits tumor relapse.

ABSTRACT: The potential of dendritic cell (DC) vaccination against cancer is not fully achieved. Little is known about the precise nature of the anti-cancer immune response triggered by different natural DC subsets and their relevance in preventing postsurgical tumor recurrence. Here, we use mouse splenic conventional DC1s (cDC1s) or cDC2s pulsed with tumor cell lysates to generate DC vaccines. cDC1-based vaccination induces a stronger effector and memory CD4⁺ and CD8⁺ anti-tumor T cell response, leading to a better control of tumors treated either therapeutically or prophylactically. Using an experimental model of tumor relapse, we show that adjuvant or neoadjuvant cDC1 vaccination improves anti-tumor immune memory, particularly by increasing the infiltrates of CD4⁺

SUBMITTER: Heras-Murillo I 

PROVIDER: S-EPMC11982544 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature