Immune training enhances anti-viral responses and improves outcomes in Pax5^-/+ mice susceptible to chronic infection.

ABSTRACT: Viral infections pose a significant global burden. Host susceptibility to pathogens is determined by many factors including genetic variation that can lead to immunodeficient or dysregulated antiviral immune responses. Pax5 heterozygosity (Pax5^-/+), resulting in reduced PAX5 levels in mice, mimics germline or somatic PAX5 dysregulation contributing to diseases such as childhood B-cell precursor acute lymphoblastic leukemia (B-ALL). In contrast to the well-characterized roles of PAX5 during early B-cell development, little is known about how Pax5 heterozygosity impacts antiviral responses. We infected Pax5^-/+ mice with the noncytopathic Lymphocytic Choriomeningitis Virus (LCMV) and found that infection with the chronic Docile strain resulted in decreased survival of Pa

SUBMITTER: Lu Z 

PROVIDER: S-EPMC11982562 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature