Post-Stroke Recovery in Relation to Parvalbumin-Positive Interneurons and Perineuronal Nets.

ABSTRACT:

Background

There is a critical time window of post-stroke neuroplasticity when spontaneous behavioral recovery occurs. Potential factors responsible for this heightened plasticity are the reduction of parvalbumin-immunoreactive (PV+) interneuron inhibitory signaling and the disappearance of extracellular matrix synaptic stabilizers called perineuronal net(s; PNN/PNNs).

Objective

This study investigated whether behavioral recovery during this critical period following stroke is associated with changes in densities of PV+ interneurons and PNNs.MethodsMale, Sprague-Dawley rats received forelimb motor cortex stroke (n = 43) using endothelin-1, or vehicle injections (n = 44). Cohorts of rats underwent a battery of motor tests and were sacrificed within the post-stroke critical wi

SUBMITTER: Kuhl LM 

PROVIDER: S-EPMC11982584 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature