A Novel Polymersome Nanocarrier Promotes Anti-Tumour Immunity by Improved Priming of CD8 ⁺ T Cells.

ABSTRACT: Cancer is one of the leading causes of death worldwide. In recent years, immune checkpoint inhibitor therapies, in addition to standard immuno- or chemotherapy and surgical approaches, have massively improved the outcome for cancer patients. However, these therapies have their limitations and improved strategies, including access to reliable cancer vaccines, are needed. Here, we describe the use of self-assembling artificial cell membrane (ACM) polymersomes to deliver tumour-specific peptides to trigger sustainable and efficient anti-tumour immune responses. We found that ACM polymersomes were highly efficient in targeting and activating mononuclear phagocytes (MNP) including dendritic cells (DC), while providing long-term reservoirs of antigens for continued immune cell priming. Subcutane

SUBMITTER: Dress RJ 

PROVIDER: S-EPMC11982605 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature