Zinc Silicate-Loaded Microneedle Patch Reduces Reactive Oxygen Species Production and Enhances Collagen Synthesis for Ultraviolet B-Induced Skin Repair.

ABSTRACT: UVR-related skin damage is common in daily life. Excessive sunlight exposure, particularly in response to ultraviolet B (UVB) radiation, can have adverse effects on the skin and can even induce photosensitive skin diseases and skin malignancies. UVB exposure leads to the production of reactive oxygen species (ROS) in the skin, resulting in cell damage and inflammation. Furthermore, it directly inhibits the synthesis of collagen in skin fibroblasts, contributing to collagen degradation and subsequently causing skin aging, wrinkles, and erythema. To address this issue, our study introduces a biomaterial-based treatment plan for repairing UVB-induced photodamaged skin. We designed a sodium hyaluronate microneedle patch containing a hardystonite bioceramic (ZnCS/MN) with anti-ROS/inflammation/

SUBMITTER: Chen FZ 

PROVIDER: S-EPMC11982614 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature