Industrial Trans Fatty Acids Promote the Development of Food Allergy in a Mouse Model.

ABSTRACT:

Purpose

The rising prevalence of food allergy (FA) has prompted investigations into dietary factors such as trans fatty acids (TFAs). While ruminant TFAs may protect against allergies, the role of industrial TFAs remains unclear. This study evaluated the effects of industrial TFAs on FA in a murine model.

Methods

20 Balb/c mice were divided into 4 groups: control (standard diet), OVA (ovalbumin-sensitized, standard diet), TFAs (industrial TFA-enriched diet), and TFAs+OVA (TFA diet + OVA sensitization). After two weeks, OVA and TFAs+OVA groups underwent OVA sensitization/challenge. Symptoms (anal temperature drop, diarrhea), serum immunoglobulin E (tIgE, OVA-sIgE), cytokines, immune cell profiles, and gut microbiota were analyzed.

Results

The incidence rates of anal te

SUBMITTER: Fu W 

PROVIDER: S-EPMC11982643 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature