Potential therapeutic targets for bladder cancer: a proteome-wide Mendelian randomization study.

ABSTRACT: The incidence of bladder cancer (BCa) is increasing worldwide and the development of drug targets for BCa is necessary. We conducted a proteome-wide association study (PWAS) mainly using mendelian randomization (MR) to explore the causal proteins associated with BCa. Protein quantitative trait locis (pQTLs) were derived from two large proteome genome-wide association studies. After validation by multiple sensitivity analysis and two replication analyses, we identified five plasma proteins showed significant causal associations with BCa. Our study indicated that GSTM4 (OR = 0.81 (0.74-0.89), P = 5.14 × 10^-6, PPH4 = 0.89) emerged as the most reliable target. Besides, PSCA, LY6D, SLURP1 and GSTM1 also showed clear causal association but only failed in colocalization. We also

SUBMITTER: Liu JH 

PROVIDER: S-EPMC11982716 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature