GCN5-related histone acetyltransferase HOOKLESS2 regulates fungal resistance and growth in tomato.

ABSTRACT: The functions of histone acetyltransferases (HATs) in the genetic control of crop traits and the underlying mechanisms are poorly understood. We studied the function of tomato HOOKLESS2 (SlHLS2), a member of the GCN5 family of HATs, through genetic, molecular and genomic approaches. Tomato hls2 mutants generated through CRISPR-cas9 gene editing show enhanced susceptibility to fungal infection, accelerated dark-induced senescence, grossly altered plant architecture, and loss of fertility accompanied by high levels of auxin accumulation. Components of the basal and induced transcriptome underlying the extensive phenotypic impact of HLS2 were uncovered. HLS2-dependent differentially expressed genes were enriched for genes implicated in photosynthesis, protein ubiquitination, oxylipin biosynth

SUBMITTER: Jaiswal N 

PROVIDER: S-EPMC11982796 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature