Testis-enriched <i>Socs7</i> is not essential for spermatogenesis and male fertility in mice.

ABSTRACT:

Objectives

As a crucial member of the Suppressor of Cytokine Signaling (SOCS) family, SOCS7 regulates various physiological processes, including insulin resistance, inflammation, and tumor suppression. However, its role in male germ cells remains poorly understood. This study aims to investigate the function of SOCS7 in spermatogenesis and uncover its potential regulatory mechanisms.

Methods

We conducted bioinformatics analyses to examine the expression profile of Socs7 in the testes, generated Socs7-knockout (KO) mice using CRISPR/Cas9 genome editing, and assessed testicular morphology through histological and immunohistochemical staining. Semen quality was evaluated using computer-assisted sperm analysis (CASA), and testicular apoptosis was examined using the

SUBMITTER: Zhou N 

PROVIDER: S-EPMC11982883 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature