<i>Spsb3</i> is not essential for spermatogenesis and male fertility in mice.

ABSTRACT:

Background

Spermatogenesis, the process by which male germ cells develop into mature spermatozoa, is a complex and highly regulated phenomenon crucial for male fertility. Various molecular pathways, including ubiquitination, play critical roles in this process. Ubiquitination regulates multiple stages of spermatogenesis by controlling cell remodeling and protein metabolism. SplA/ryanodine receptor domain and SOCS box containing 3 (SPSB3), a SOCS box protein, interacts with ElonginC/B and recruits Cullin5 to form the ECS E3 ligase complex, which is involved in cell development, proliferation, stress response, and apoptosis. However, the specific role of SPSB3 in spermatogenesis and male reproduction remains poorly understood.

Methods

The distribution and expression of Spsb

SUBMITTER: Jiang B 

PROVIDER: S-EPMC11982890 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature