Causal relationship between hand grip strength and cognition/dementia risk: a Mendelian randomization study.

ABSTRACT:

Background

Muscle strength positively correlates with cognitive function, with the bidirectional causal link between hand grip strength and cognition posing a significant but incompletely understood public health challenge. This study aimed to explore the causal relationship between hand grip strength and cognition and its effect on dementia.

Methods

A two-sample Mendelian randomization analysis used genome-wide significant single nucleotide polymorphisms (SNPs) (P < 5×10^-8, at least P < 5×10^-6) linked to hand grip strength (right or left), cognition/dementia risk from the IEU Open GWAS project with 42,484 GWAS summary data sets. The primary analysis employed the inverse variance weighted method, while sensitivity analyses were conducted using the weigh

SUBMITTER: Sun Q 

PROVIDER: S-EPMC11982891 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature