Pomegranate-Derived Exosome-Like Nanovesicles Containing Ellagic Acid Alleviate Gut Leakage and Liver Injury in MASLD.

ABSTRACT: Exosome-like nanovesicles derived from plants (PENs) harbor a spectrum of bioactive compounds, including proteins, lipids, nucleic acids (such as miRNAs and mRNAs), offering therapeutic advantages for a variety of diseases. This investigation assesses the utility of pomegranate-derived exosome-like nanovesicles (PNVs) in both preventing and treating complications such as liver damage and increased intestinal permeability found in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). Utilizing Transmission Electron Microscopy (TEM) and Nanoparticle Tracking Analysis (NTA), we successfully isolated PNVs and characterized their structural properties. Upon administration in a live model, these nanovesicles were efficiently distributed to critical organs, including the liver and int

SUBMITTER: Kim JS 

PROVIDER: S-EPMC11982932 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature