Co-occurrence of thymoma and acute T-lymphoblastic leukemia/lymphoma: a case report and literature review.

ABSTRACT:

Background

A thymoma is a tumor originating from thymic epithelial cells variably associated with non-neoplastic lymphocytes. T-lymphoblastic leukemia/lymphoma (T-LBL) is thought to arise from precursor T-cells from bone marrow-derived hematopoietic stem cells that migrate to the thymus. While the association of secondary hematopoietic malignancies in thymoma is well established, only rarely in the literature have T-LBL and thymoma been seen in association and the relationship is poorly understood. Occasionally, distinction between the two can be difficult as immature lymphocytes in thymoma resemble T-LBL both morphologically and immunophenotypically. An accurate diagnosis is essential as treatments vary between these two entities.

Case description

We present the interesting

SUBMITTER: Frazzette N 

PROVIDER: S-EPMC11982990 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature