Development and Evaluation of Thrombin-Loaded Gelatin Hemostatic Sheets for Spinal Surgery Applications.

ABSTRACT:

Introduction

During spinal surgery, management of intraoperative bleeding and effective hemostasis are required to clearly visualize the surgical field and to safely perform procedures and positive postoperative outcomes. However, it is challenging to stop bleeding from the venous plexus around the dural sac due to the potential risk of neural tissue damage. We aimed to develop hemostatic sheets with appropriate characteristics for spinal surgery, such as softness, appropriate thickness, biodegradability, thrombin bioactivity, and minimal water-induced expansion.

Methods

Hemostatic sheets were made by dissolving bovine bone-derived gelatin in water and aerating it to form foam, followed by freeze-drying, crosslinking, and thrombin-soaking. Sheets A to H were produced with di

SUBMITTER: Kawabata A 

PROVIDER: S-EPMC11983116 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature