Unlocking New Pharma/Nutraceutical Frontiers With Neuroprotective Properties of Three <i>Hypericum</i> Species: A Study Combination With In Vitro and In Silico Methodologies.

ABSTRACT: This study investigates the phytochemical composition and biopharmacological potential of three Hypericum species (H. scabrum, H. lysimachioides, and H. uniglandulosum) from Turkey. Aqueous and hydroalcoholic extracts were analyzed for their total phenolic content (TPC), total flavonoid content (TFC), and individual components (by the UHPLC-HRMS technique). Antioxidant activities were investigated by DPPH, ABTS, CUPRAC, FRAP, phosphomolybdenum, and metal chelating assays. The inhibition effects of the tested extracts on acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase, amylase, and glucosidase were examined. One hundred compounds were identified in the chemical composition, and specific compounds for the genus Hypericum, such as hyper

SUBMITTER: Bahsi M 

PROVIDER: S-EPMC11983157 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature