Genetic Predisposition to Low-Density Lipoprotein Cholesterol and Incident Type 2 Diabetes.

ABSTRACT:

Importance

Treatment to lower high levels of low-density lipoprotein cholesterol (LDL-C) reduces incident coronary artery disease (CAD) risk but modestly increases the risk for incident type 2 diabetes (T2D). The extent to which genetic factors across the cholesterol spectrum are associated with incident T2D is not well understood.

Objective

To investigate the association of genetic predisposition to increased LDL-C levels with incident T2D risk.

Design, setting, and participants

In this large prospective, population-based cohort study, UK Biobank participants who underwent whole-exome sequencing and genome-wide genotyping were included. Participants were separated into 7 groups with familial hypercholesterolemia (FH), predicted loss of function (pLOF) in APOB or PCSK

SUBMITTER: Ravi A 

PROVIDER: S-EPMC11983226 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature