Multimodal Monitoring of Hemodynamics in Neonates With Extremely Low Gestational Age: A Randomized Clinical Trial.

ABSTRACT:

Importance

Evaluation and treatment of transitional circulation in neonates with extremely low gestational age (ELGA) varies greatly across centers.

Objective

To determine whether multimodal hemodynamic monitoring in neonates with ELGA during the transitional period (first 72 hours of life) will improve cardiorespiratory-kidney health by decreasing vasoactive-ventilation-renal (VVR) score at 7 days.

Design, setting, and participants

This unmasked, 2-arm randomized clinical trial included neonates born at a gestational age of 230 to 286 weeks and admitted to a neonatal unit in Canada. Patients were enrolled from February 15, 2019, to December 31, 2021, with follow-up completed in April 2022.

Interventions

Neonates in the multimodal arm received early targeted ne

SUBMITTER: Lalitha R 

PROVIDER: S-EPMC11983231 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature