Universal Prophylactic Antitumor Vaccination Using Stem Cell Membrane-Coated Nanoparticles.

ABSTRACT: Cancer vaccines are a promising immunotherapeutic modality that function by training the immune system to recognize and destroy malignant cells. As tumor-specific and tumor-associated antigens generally cannot be identified until after a tumor has already been established, these vaccines must be applied therapeutically when strong immunosuppressive mechanisms are already in place. Building upon previous work using cell membrane coating nanotechnology, the development of a broad-spectrum prophylactic cancer nanovaccine that consists of induced pluripotent stem cell (iPSC) membrane coated around an adjuvant-loaded nanoparticle core is shown. The resulting nanostructure is capable of presenting iPSC-derived oncofetal antigens, which are oftentimes re-expressed on cancer cells but lowly presen

SUBMITTER: Krishnan N 

PROVIDER: S-EPMC11983251 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature