Exploratory Study of Sex Differences in P-Glycoprotein Function at the Blood-Brain Barrier.

ABSTRACT: Permeability-glycoprotein (P-gp), a crucial efflux pump transporter encoded by the ABCB1 gene, plays a pivotal role in drug disposition at the blood-brain barrier (BBB) and is involved in the pharmacokinetics of numerous therapeutic agents. This study investigates differences in P-gp function at the BBB between males and females in a cohort of older (55+) healthy volunteers (HV) using [¹⁸F]MC225 and PET. Twenty HV (11 males and 9 females), free from medications that affect P-gp function and without a history of neurological or psychiatric disorders, underwent [¹⁸F]MC225 PET scans with manual arterial blood sampling. Tissue time-activity curves (TAC) were extracted using the Hammers maximum-probability atlas. Whole-blood TAC was derived from the internal carotid arteri

SUBMITTER: Salvi de Souza G 

PROVIDER: S-EPMC11983324 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature