Enhanced Antitumor and Antibacterial Activities of Ursolic Acid through β-Cyclodextrin Inclusion Complexation.

ABSTRACT: Ursolic acid (UA) is a pentacyclic triterpenoid known for its wide range of biological activities, including anticancer and antimicrobial effects. However, its poor solubility in water limits its therapeutic potential. Therefore, this work aims to evaluate the physicochemical properties of the ursolic acid/β-cyclodextrin inclusion complex (UA/βCD IC) and investigate the enhancement of the in vitro antitumor and antibacterial activities of UA when complexed with βCD. Molecular docking simulation showed that the carbonyl group of UA binds to the internal cavity of βCD, forming a hydrogen bond with the glucosidic residues of βCD. FTIR analysis revealed significant changes in the absorption peaks of UA/βCD IC, indicating interaction between the compounds, such as the reduction in intens

SUBMITTER: Fajardo JB 

PROVIDER: S-EPMC11983339 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature