Advancements in Noninvasive Volatile Organic Compound Detection: Integrating Stirling Cooling Preconcentration with GC-FID/MS for Quantitative Breath Analysis.

ABSTRACT: The study of volatile organic compounds (VOCs) in exhaled breath presents significant potential for noninvasive disease diagnosis and human exposure monitoring. While thermal desorption (TD) tubes are the most commonly used preconcentration technique for analyzing VOCs in breath, they still face practical challenges, mainly selective adsorption and interference from water vapor in breath samples. This study is the first to develop a method combining Stirling cooling preconcentration technology with gas chromatography-flame ionization detector/mass spectrometry (GC-FID/MS) and a SUMMA canister, enabling simultaneous detection of 116 VOCs. The method requires no refrigerants and effectively addresses the selective adsorption and water vapor interference issues found with TD tubes. Furthermor

SUBMITTER: Xu Q 

PROVIDER: S-EPMC11983350 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature