Gastric carcinoma harbouring loss‑of‑function mutations in the <i>PIK3R1</i>, <i>ATRX</i> and <i>RBM10</i> genes exhibits diverse histological features associated with EBV infection and <i>TP53</i> inactivation: A case report.

ABSTRACT: This study presents a novel case of gastric carcinoma (GC) with diverse histological features and unique molecular alterations. A 62-year-old man with hematemesis was diagnosed with advanced GC and hepatic metastasis. Despite palliative gastrectomy to control bleeding, the patient succumbed within 6 months. Histological examination revealed three distinct tumour components: Gastric adenosquamous carcinoma (GASC), GC with lymphoid stroma (GCLS) and poorly differentiated adenocarcinoma (PDAD). Immunohistochemical staining, next-generation sequencing and Epstein-Barr virus (EBV) in situ hybridisation were performed to characterise the tumour. The GASC component revealed diffuse p40 and p63 immunoreactivity, while the GCLS and PDAD components were negative for both markers. All componen

SUBMITTER: Jeong SU 

PROVIDER: S-EPMC11983370 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature