Unraveling salivary microbiota diversity following kidney transplantation: insights from baseline peripheral blood lymphocyte subsets.

ABSTRACT:

Background

Effective biomarkers are urgently needed to monitor immune suppression in kidney transplantation (KT) recipients. Our study identified a close association between the salivary microbiota and immunosuppressant concentrations. It is therefore hypothesized that the salivary microbiota may be linked to immune function.

Materials and methods

We analyzed 108 saliva samples from 37 KT patients using 16S rRNA sequencing. Patients were clustered via K-means based on peripheral blood lymphocyte subset (PBLS) counts.

Results

Cluster1 exhibited significantly higher CD4⁺ T cells (p < 0.0001), CD8⁺ T cells (p < 0.0001), and B cells (p = 0.0071) versus Cluster2, with marginally NK cells (p = 0.2319). Beta diversity indicat

SUBMITTER: Xiang X 

PROVIDER: S-EPMC11983535 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature