Screening and mechanistic study of natural compounds that enhance T cell anti-tumor effects post-heat treatment.

ABSTRACT:

Introduction

Following the approval of Chimeric Antigen Receptor T-cell Immunotherapy(CAR-T) in multiple countries, the Food and Drug Administration (FDA) approved tumor-infiltrating lymphocytes (TILs) and T-cell receptor-engineered T cells (TCR-T) treatments this year. The utilization of adoptive immunotherapy in tumor treatment has become increasingly prominent. Optimizing the cytotoxic effects of immune cells under in vitro culture conditions represents a current hot research topic in this domain.

Methods

In the current experiment, we conducted in vitro heat treatment on Jurkat-derived T cells at 39°C. On this basis, we utilized nine distinct injectable solutions and over 70 monomer components of Traditional Chinese Medicine (TCM). Subsequently, we co-cultur

SUBMITTER: Wang Z 

PROVIDER: S-EPMC11983556 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature