Longitudinal cellular and humoral immune responses following COVID-19 BNT162b2-mRNA-based booster vaccination of craft and manual workers in Qatar.

ABSTRACT:

Background

In March 2020, the rapid spread of SARS-CoV-2 prompted global vaccination campaigns to mitigate COVID-19 disease severity and mortality. The 2-dose BNT162b2-mRNA vaccine effectively reduced infection and mortality rates, however, waning vaccine effectiveness necessitated the introduction of a third vaccine dose or booster.

Aim

To assess the magnitude and longevity of booster-induced immunity, we conducted a longitudinal study of SARS-CoV-2 specific cellular and humoral immune responses among Qatar's vulnerable craft and manual worker community. We also investigated the impact of prior naturally acquired immunity on booster vaccination efficacy.

Methods

Seventy healthy participants were enrolled in the study, of whom half had prior SARS-CoV-2 infection. Bloo

SUBMITTER: Thomas R 

PROVIDER: S-EPMC11983602 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature